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Relapse of Major Depression During Pregnancy in Women Who Maintain or Discontinue Antidepressant Treatment

Journal of the American Medical Association — Vol 295, No. 5

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Context
Pregnancy has historically been described as a time of emotional wellbeing, providing “protection” against psychiatric disorder. However, systematic delineation of risk of relapse in women who maintain or discontinue pharmacological treatment during pregnancy is necessary.

Objective
To describe risk of relapse in pregnant women who discontinued antidepressant medication proximate to conception compared with those who maintained treatment with these medications.

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